Conference commissioner Jon Steinbrecher said the league would continue to avoid conducting business in the Hoosier state until, "the current matter is brought to a sensible and appropriate conclusion."
Steinbrecher told NCAA President Mark Emmert of the league's decision and urged Emmert to relocate the NCAA away from its national headquarters, which are currently in Indianapolis, the report said.
Ball State University is the only school in the conference located in the state of Indiana.
This year's MAC basketball championship was held in Cleveland. The conference's football championship game has been held in Detroit for the past 11 years.
The news comes on the same day that USC athletic director Pat Haden, a member of the College Football Playoff Committee, announced he would boycott the committee's meeting in Indianapolis this week. Haden's son is gay.
Critics of Indiana's law believe it will be used to discriminate against LGBT individuals.
- Will Green