Florida State transfer Jacob Coker will play as well, but is expected to come off the bench. The news comes a day after Coker and Sims were listed as co-starters on the Crimson Tide's first depth chart.
Sims and Coker have been competing for the position following the departure of three-year starter A.J. McCarron, who is now in the NFL.
CBS Sports reports that the next three practices could "change the outlook," and that redshirt sophomore Alec Morris could also play Saturday if neither Sims nor Coker are getting the job done.
Sims saw action in eight games last season, rushing for 61 yards on 15 carries and completing 18 of 29 passes for 167 yards and two touchdowns.
Coker spent last season behind Jameis Winston in Tallahassee after losing what Seminoles coach Jimbo Fisher called a tight quarterback race.
The Crimson Tide are ranked second in the preseason AP poll.
- Molly Geary