Both players will have to undergo surgery.
Dunning has been playing in a reserve role this season, while Harris has caught nine passes for 55 yards.
The Cyclones also lost their top receiver, Quenton Bundrage, for the season with a torn ACL earlier this month.
OL Jacob Dunning (ruptured patellar tendon) and WR P.J. Harris (broken bone, leg) both likely done for the season for Iowa State. — David Ubben (@davidubben) September 15, 2014
- Chris Johnson