Maddy played through a torn meniscus in Tech's 27-25 loss to Georgia Tech last week. He has nine tackles and 0.5 tackles for loss this season.
Nigel Williams will replace Maddy as the starter at tackle.
The Hokies are 2-2. The team won its first two games, including a victory at Ohio State, before losing two straight home games.
Virginia Tech hosts Western Michigan on Saturday.
- Sarah Barshop