Choice injured his knee on a carry in the first quarter against the Eagles and did not return.
Choice was a touted recruit in the class of 2014, ranked by Rivals.com as the No. 109 player and No. 10 running back in the country. He gradually emerged as the Tigers' top option at the position after presumed starter Zac Brooks was lost for the season with a foot injury during fall camp. The team lost last season's top rusher Roderick McDowell to graduation.
Clemson is also currently without starting quarterback DeShaun Watson, who's likely out until mid-November with a broken finger.
The Tigers defeated Boston College 17-13 on Saturday and are now 5-2 this season. Clemson hosts Syracuse this Saturday.
- Ben Estes