The Tigers will visit Morgantown to play the 2016 season-opener against West Virginia on Sept. 3, 2016. The Mountaineers will complete the series on Sept. 7, 2019, when they travel to Columbia to take on the Tigers.
Missouri executive associate athletic director Bryan Maggard said the series would appeal to fans and bolster the profiles of both schools.
“We are very pleased to add a team the caliber of West Virginia to our schedule. We feel like this is a game that is appealing to the fan bases of both programs, and it helps us both add high-profile non-conference games to our schedules," Maggard said.
"We’re excited to have a chance to work together, and appreciate everyone coming together to make this happen on all sides."
Missouri holds a 3-2 advantage in the all-time series between the two programs; the Tigers won the most recent game, a 34-31 victory in the 1998 Insight Bowl.
The Tigers are 7-2 overall and 4-1 in the SEC this season, while West Virginia has compiled a 6-3 record, going 4-2 in Big 12 conference play.