Tigers coach Dabo Swinney said this week that Watson had a chance to play in the game but was not definitive.
Senior Cole Stoudt replaced Watson in the loss to the Yellow Jackets and completed 19 of his 29 pass attempts for 132 yards with a touchdown and an interception in the win over the Panthers.
Watson has thrown for 1,197 yards with 12 touchdowns and two interceptions this season. He was rated the No. 1 dual-threat quarterback in the class of 2014 by Rivals.com.
Clemson (8-3, 6-2 ACC) is ranked 21st in the latest edition of the College Football Playoff rankings. The Tigers have lost five consecutive games against South Carolina (6-5, 3-5 SEC).
- Chris Johnson