Treadwell, a junior, missed the final four games of the 2014 season due to a fractured fibula and dislocated ankle. At the time of his injury, Treadwell was leading Ole Miss with 48 receptions, 632 yards and five receiving touchdowns through nine games.
Treadwell has returned this season in full health and currently ranks near the top of the SEC with a career-best 76 receptions, 1,082 yards and eight touchdowns in 2015.
To qualify for early draft eligibility, Treadwell and all other underclassmen must apply by Jan. 18.
The Rebels meet the Oklahoma State Cowboys on Jan. 1 in the Sugar Bowl at the Mercedes-Benz Superdome in New Orleans.