Alexander, the Tigers’ top cornerback, walked slowly off the field and was attended to by trainers during the first half. He was then seen at the trainer’s table with ice taped to his left hamstring.
It was later announced at the start of the third quarter that Alexander would not return to the game.
Alexander entered Monday as a game-time decision due to an injury to his right hamstring, which he originally sustained in November.
The redshirt sophomore’s injury flared up during Clemson’s semifinal win over Oklahoma.