Colorado enters Saturday's contest against USC ranked for the first time since November 2005 and is currently the only undefeated team in league play in the Pac-12's South Division.
Colorado entered the 2016 season winning only five of its first 40 Pac-12 games since entering the league in 2011.
The surprising Buffaloes (4–1, 2-0 Pac–12) routed Oregon State 47–6 last week, led by redshirt freshman quarterback Steven Montez who threw for 293 yards and three touchdowns.
The Trojans (2–3, 1–2 Pac–12) are also going with their own freshman quarterback in Sam Darnold, who racked up 352 yards and three touchdowns of his own.
All-America candidate Juju Smith-Schuster caught all three touchdown passes from Darnold in a 41–20 win against Arizona State, which broke a two-game losing streak.
USC has won all 10 meetings between the schools. See how to watch Saturday's game below.
How to watch
When: 4 p.m. ET
TV: Pac-12 Network
Live stream: Watch the game online here.
Colorado: vs. Arizona State (10/15), at Stanford (10/29), vs. UCLA (11/3)
USC: at Arizona (10/15), vs. California (10/27), vs. Oregon (11/5)