SI.com's David Sabino and James Quintong select their ultimate fantasy lineup each week, with one twist -- they can use any player once and only once during the season. Play along with us on the Fantasy Football Player Pick 'Em game and join the SI.com Power Players group.
Jay Cutler, Broncos
Michael Vick, Falcons
The last rookie to throw at least two TD passes in his first three starts was Dan Marino. I like his chances of extending the streak against the Bengals.
The groin injury is an issue. However, he has big games in spurts, and takes on a Panthers team that is fading at the wrong time and lost Mike Rucker to an ACL tear.
Ladell Betts, Redskins
Ron Dayne, Texans
The league's top injury replacement has four straight 100-yard rushing games and there's little reason to think that he won't make it five against the Rams.
The Colts run defense improved Monday night, but we'll see how much if it can't stop the former Heisman winner, who's been rejuvenated in recent weeks.
Brandon Jacobs, Giants
Thomas Jones, Bears
He won't gain many yards but he has the ability to bull his way into the end zone multiple times. It'll be that way in this high-scoring game against the Saints.
He may be sharing more time with Cedric Benson, but against the Lions, there's plenty of room for big numbers as Detroit looks to get the No. 1 overall draft pick.
Reggie Brown, Eagles
Reggie Brown, Eagles
Has clicked with Jeff Garcia and has three touchdowns in his last four games. Look for the trend to continue against Dallas in this battle for the division title.
The Cowboys have been susceptible to the pass the past couple of weeks, and Brown has been Jeff Garcia's favorite receiver since becoming the starter.
Muhsin Muhammad, Bears
Joey Galloway, Buccaneers
Now that Rex Grossman has straightened himself out, Muhammad has lots of value again, especially against one of the league's worst teams in Detroit.
A big hit-or-miss receiver each week. However, he had a couple of big plays with Tim Rattay at QB and now faces a very soft Cleveland pass defense.
Bryan Fletcher, Colts
Vernon Davis, 49ers
Indy's TEs were quiet against Cincinnati. Look for Fletcher and Ben Utecht to see lots of action against Houston, especially if Joseph Addai can't answer the bell.
The rookie has come along lately since returning from a broken leg and is building up some decent numbers to be a high draft pick next year.
Stephen Gostkowski, Patriots
Josh Scobee, Jaguars
This should be a low scoring field-goal affair which made it a tough choice between the New England rookie and Jacksonville's Josh Scobee.
Tied for third in the league in field goals made and the Patriots could keep the sometimes iffy Jaguars in check, at least near the goal line.
Three return TDs last week? Pacman Jones is one of the few defensive/special teams gamebreakers in the league and can do it again against the Bills this week.
Their run defense improved on Monday night and now they face a Texans offense in complete disarray. Look for plenty of turnovers and sacks from David Carr.
Last week's scores: Sabino 1067, Quintong 705
Season to date scores: Sabino 15614, Quintong 15388
We've Got Apps Too
Get expert analysis, unrivaled access, and the award-winning storytelling only SI can provide - from Peter King, Tom Verducci, Lee Jenkins, Seth Davis, and more - delivered straight to you, along with up-to-the-minute news and live scores.