As Wilson attempts to win his fourth straight decision at home, the Angels go for their 11th victory in 14 games Friday night in the opener of a three-game set with the Royals.
Wilson (5-3, 3.16 ERA) struck out seven in a five-hitter as he threw 127 pitches - the second-most of his career - in Saturday's 6-0 win over visiting Tampa Bay.
"I happened to throw a lot of pitches because I can manipulate my mechanics to take stress off here and there, try to change speeds and not throw every pitch as hard as I can," said Wilson, averaging a major league-high 117.4 pitches per game.
In his last four home starts, Wilson has gone 3-0 with a 1.69 ERA. He hasn't given up a homer in any of those games, compared to five allowed in his four road outings.
Now the left-handed workhorse will try to make another solid contribution to a Los Angeles rotation that has a 2.69 ERA during this 10-3 stretch, holding opponents to a .193 average. Wilson is 3-0 with a 2.80 ERA in five career starts versus Kansas City (23-23).
Duffy (2-3, 1.42) is 1-2 with a 1.06 ERA in three starts since joining the rotation.
The left-hander worked 6 2-3 perfect innings Saturday before Baltimore's Adam Jones broke up the bid with a single. He went on to allow two hits without a walk over seven-plus innings in a 1-0 victory.
Duffy hopes to carry over that success into his outing against the Angels (26-20), whom he faces for the first time.
"They're a pretty good team," he told the Royals' official website. "The Orioles were hitting the ball pretty well, too, so I know what I have in the tank, and I'm going to try to execute to the best of my ability."
The Royals, who have totaled 23 runs in their last four games while hitting .366 with runners in scoring position, could welcome back Omar Infante and Salvador Perez as early as Friday. Infante had a team-high 19 RBIs before going on the disabled list May 7 because of a sore back, and Perez - tied for the team lead with four home runs - has missed the last two games with a sore thumb.
The Royals salvaged the finale of a three-game home series Wednesday with a 3-1 win over the Chicago White Sox.
Billy Butler drove home the go-ahead run with a sacrifice fly in the eighth inning and is 8 for 15 over the last four games. He's 10 for 17 with two homers in his last four in Anaheim.
Angels slugger Albert Pujols looks to stay hot after his sixth-inning home run was the difference in a 2-1 victory over Houston on Wednesday. Pujols, 7 for 16 with three homers in his last four games, has hit .344 with 18 home runs and 60 RBIs in 66 career matchups with Kansas City.
Mike Trout should be ready after resting his ailing hamstring Wednesday. The star outfielder has batted .340 with four home runs in 13 career games against the Royals.
The Angels went 5-2 versus Kansas City last season, though the Royals took two of three in Anaheim.