Justin Masterson has endured his share of problems against the Tampa Bay Rays.
His Boston Red Sox are about to get their first look at a pitcher they've never seen - one who has never lost on the road.
Masterson will square off against Alex Colome in Wednesday night's series finale at Fenway Park.
Masterson's career 6.83 regular-season ERA against the Rays is his worst against any AL club. Tampa Bay has been a nemesis for him as well in the postseason, eliminating his clubs in 2008 and 2013.
The right-hander is 2-6 with a 7.07 ERA in 10 career starts against the Rays. Evan Longoria has the most experience against him among Tampa Bay hitters, going 7 for 23 with a homer in regular-season play.
David DeJesus (2 for 11), Asdrubal Cabrera (3 for 5) and James Loney (0 for 2) are the only other available Tampa Bay hitters who have faced Masterson.
That's more experience than Boston (13-14) has versus Colome, who has never faced a Red Sox hitter and is 3-0 with a 0.41 ERA in four career road starts.
That does not include the right-hander's "road" outing Friday at home against the Orioles in which he worked five innings in a 2-0 victory in a contest moved to Tampa Bay due to the unrest in Baltimore. Colome made his season debut after being reinstated from the 15-day disabled list after he was hospitalized during spring training with pneumonia.
"I can't wait to see him again next time," manager Kevin Cash told MLB's official website.
Masterson (2-0, 4.71 ERA) yielded two runs over six-plus innings in Friday's 3-2 home defeat to the New York Yankees.
These teams split two games to start this series, with Tampa Bay (14-13) winning 5-1 on Monday and Boston ending a four-game slide the next night with a 2-0 victory.
The Red Sox are without Hanley Ramirez, who sprained his left shoulder running into a wall Monday and won't be back until Friday at the earliest. Ramirez's 10 homers are double the total of anyone else on the club.
Allen Craig started in his place and went 1 for 2 with a walk to increase his average to .163.
Mookie Betts was Tuesday's hitting star with his first career multihomer effort. He is 11 for 33 with eight RBIs in his last eight games.
"I think we just needed a win," he said. "But a win like this was huge."
Pablo Sandoval is hitless in eight at-bats in this series and 2 for 20 against the Rays this year while David Ortiz is 3 for 19 in the season series.
Dustin Pedroia went 0 for 3 with a walk Tuesday after batting .400 during an eight-game hitting streak.
DeJesus is 4 for 8 in this series and Steven Souza Jr. is 4 for 7 for Tampa Bay, which has totaled 15 runs in a 3-5 stretch.
Longoria recorded his 1,000th hit Tuesday and is in third place in franchise history, 16 behind Ben Zobrist.
"That's pretty cool," Cash said. "Hopefully he gets another thousand in that time frame. He's a pretty impressive baseball player."