CHICAGO (AP) Chicago Cubs starter Edwin Jackson left Thursday night's game against the San Diego Padres with no outs in the sixth inning because of cramping in his right hand.

With San Diego leading 3-1, Yasmani Grandal led off the sixth with a walk, then Will Venable singled to right.

Immediately after the hit, Cubs manager Rick Renteria and a trainer came to the mound, and Jackson left the game. He was replaced by Brian Schlitter.

SI Apps
We've Got Apps Too
Get expert analysis, unrivaled access, and the award-winning storytelling only SI can provide - from Peter King, Tom Verducci, Lee Jenkins, Seth Davis, and more - delivered straight to you, along with up-to-the-minute news and live scores.