DeJesus has been out with a fractured left hand since June 18. He has missed 64 of the Rays games and had been rehabbing at Single-A Charlotte.
In 62 games this season, the 34-year-old was batting .269 with five home runs and 17 RBIs.
According to MLB.com, DeJesus is "fully cleared" to play, and will not need to have surgery on his hand this offseason.
"It's great to play," DeJesus said. "It's going to be sore sometimes, but it's not going to break, it's not going to tear anything, so now it's just getting through it and finish the year strong. ... I just want to be with the guys. I want to help the team win."
- Sarah Barshop