Lackey carried a no-hitter into the sixth inning, and finished his night after 7 1/3 scoreless frames, allowing just two hits and a walk while striking out five.
Cubs starter Jon Lester was charged with the loss, allowing three earned runs over 7 1/3 on five hits while striking out nine.
Game 2 gets underway from St. Louis on Saturday at 5:37 p.m. ET.
- Kenny Ducey