Lee, 31, re-injured his hamstring while making his season debut on Wednesday night against the Los Angeles Clippers. He had six points in seven minutes off the bench before leaving the game. He will be re-evaluated in two weeks.
Lee originally injured his hamstring during Golden State's preseason finale last month and missed the first three games of the season.
Lee averaged 18.2 points and 9.3 rebounds last season for the Warriors.
Third-year forward Draymond Green has started in Lee's place to open the season and is averaging 12.5 points and 7.3 rebounds. He scored a career-high 24 points, including four three-pointers, during Wednesday's victory against the Clippers.
Under first-year head coach Steve Kerr, the Warriors have opened the season 4-0 and are one of just three unbeaten teams. Klay Thompson signed a four-year, $70 million contract extension last month and leads the team in scoring at 27.0 points per game. Stephen Curry is second on the team with 26.0 points per game while also averaging 7.0 assists.
The Warriors play at the Rockets on Saturday night at 8 p.m. ET.
- Paul Palladino