Aldridge has yet to miss a game this season, and his 21.9 points, 7.9 rebounds and 2.2 assists in 35.1 minutes per game through nine games this year have helped take the team to a 6-3 record.
Head coach Terry Stotts said the team sent Aldridge home from the team's Friday practice because of signs of illness that have appeared in recent days.
Aldridge has never played a complete 82-game season in his nine-year career, all of which he has spent in Portland. Last season, he missed 13 games and the team went 8-5 with him off the court.
According to Joe Freeman of the Oregonian, the likely candidate to replace Aldridge is Chris Kaman, who has appeared in all nine games this year, averaging 10.1 points and 6.8 rebounds in 19.4 minutes per game so far.
"Chris has been fantastic for us," Stotts said. "He's provided a spark (with) scoring, rebounding, energy off the bench."
"I don't necessarily want to run his minutes up into starter's minutes, (but) if [LaMarcus Aldridge] doesn't play, we're going to have to rely on him."
The Trail Blazers will face the Nets at home Saturday, Nov. 15, at 10 pm EST.