The game is part of the NBA's Global Games and will be played at London's O2 Arena at 3 p.m. ET.
Anthony has missed the last six games because of a knee injury, and Stoudemire has sat out the past nine games dealing with his own knee issues.
"It's been really good to have all of our guys in practice, healthy and feeling good about being on the court," Knicks coach Derek Fisher said.
The Knicks (5-35) have the NBA's worst record and have lost a franchise-record 15 games in a row. Anthony has said that the constant losing is not fun.
“I can’t shrug it off,” Anthony said to ESPN.com. “It hurts me. It pains me, because I care. If I didn’t care it would be easy to shrug it off.”
Anthony is averaging a team-leading 23.9 points, 6.6 rebounds, and 3.1 assists this season, while Stoudemire is averaging 13.1 and 7.4 rebounds.
- Scooby Axson