James provided the first points of the game by cutting backdoor from the right wing before rising high to finish a two-handed slam, which he embellished with a twisting chin-up on the rim and a backboard slap.
It was a strong start to what proved to be an off night for James, who battled foul trouble and finished with a playoff career-low seven points.
James shot 2-for-10 from the field and tallied four assists and two rebounds, while committing three turnovers in 24 minutes. He also endured an ear-blowing incident from Pacers guard Lance Stephenson.
Paul George registered a game-high 37 points (on 15-of-28 shooting), six rebounds, two assists and six steals to lead the Pacers to the season-extending victory. Stephenson added 12 points (on 4-for-11 shooting), five rebounds and five assists for Indiana.
Chris Bosh led the Heat with 20 points (on 9-of-21 shooting) and 10 rebounds, but he missed a potential game-winning three-pointer on Miami’s final possession. The Heat now hold a 3-2 series lead over the Pacers. Game 6 is set for Miami’s American Airlines Arena on Friday. Miami is seeking its fourth straight trip to the Finals.