However, Colts coach Chuck Pagano said Wayne will "definitely" not play in the Colts' preseason game Thursday against the New York Jets, reports Mike Wells of ESPN.
Wayne, 35, tore his right ACL last October against the Broncos. He told reporters he is confident in his recovery as preseason opens this week.
“As far as the rehab part, I've ran every route. Either it was here in Indiana, in Indianapolis or it was down in Miami,” Wayne says. “I've run every route and there is nothing that's holding me back.
“There's nothing that's keeps me from doing whatever it is they want me to do so I'm here. Knock on wood I stay on top of this and keep going from there.”
Wayne, who arrived to training camp in an Indy Car, had 38 catches, 503 yards and two touchdowns in seven games last season before injuring his knee. He has played his entire career for the Colts since being drafted with the 30th pick in the 2001 NFL draft.
Indianapolis travels to Denver to play former Colts quarterback Peyton Manning and the Denver Broncos on Sept. 7 to start the regular season.
- Paul Palladino