Spiller has not returned a kick since the 2011 season. Marquise Goodwin handled kick returns last season, gaining 351 yards on 16 attempts.
"I look at it as how many guys have been injured returning the football compared to people injured with the ball being handed off to them," Marrone said, according to the Bills website.
Spiller ran for 933 yards and two touchdowns and caught 33 passes for 185 yards last season for the Bills, who have not made the playoffs since the 1999 season.
"I don't view it as much of a risk as some people would. I could understand why people could see that because of the distance and the way people are running down the field," Marrone said. " As much as we can get our playmakers out there whether it be punt returns or kickoff returns we have to make sure we explore that."
The Bills open the season on the road Sunday against the Chicago Bears.
- Scooby Axson