According to the report, Mathis will be out "an extended period" after an MRI revealed he has a sprained right MCL, likely a Grade 3 sprain. He will get a second opinion Wednesday. Barbre has a high ankle sprain and could be out several weeks. He will reportedly see a foot specialist this week.
Both players sustained their injuries during Sunday's game against the Jacksonville Jaguars. Mathis left the game in the second quarter when he was rolled into from behind by Eagles running back LeSean McCoy.
Mathis, 32, has been with the Eagles since 2011 and was named All-Pro last season. Barbre joined the team last season. He started Sunday in place of normal right tackle Lane Johnson, who's suspended for the first four games of the season for violating the NFL's drug policy.
Backup Matt Tobin is also currently out with a high ankle sprain.
The Eagles defeated the Jaguars 34-17. Philadelphia plays at the Indianapolis Colts next Monday in Week 2.
- Ben Estes