NFL odds: Expect high-scoring affair when Colts face Eagles in MNF

The Indianapolis Colts will look to rebound from a season-opening loss to Denver and win their fifth straight home game both straight-up and against the spread when they host the Philadelphia Eagles on Monday Night Football as three-point favorites, according to sportsbooks monitored by OddsShark.com. The Colts still covered the 8.5-point line in the 31-24 setback to the Broncos, improving to 5-1 ATS in their last six games overall dating back to last year, including the playoffs.

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Indianapolis quarterback Andrew Luck played well in defeat at Denver despite throwing two interceptions, passing for 370 yards and two touchdowns and rushing for 19 yards and another score. The Colts dug themselves into a 24-0 hole just before halftime, and two fourth-quarter touchdowns were not enough to overcome that deficit against Peyton Manning and company. However, it was just enough to push the total OVER for the third straight time, including their two playoff games last season.

Meanwhile, the Eagles completed an impressive comeback in Week 1 against the Jacksonville Jaguars, rallying back from an early 17-0 deficit to not only win but also cover the 10-point spread in a 34-17 victory. Philly took control of the game midway through the fourth quarter on a 68-yard touchdown pass from QB Nick Foles to wide receiver Jeremy Maclin and then scored 10 points in the final two minutes, including a defensive TD, to beat the number with 1:23 left.

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Indy has not faced Philadelphia since losing 26-24 at Lincoln Financial Field in 2010, but the Colts have covered the last five meetings and had won the previous four SU before that. The total has gone OVER in each of the last five games between the teams as well, according to the OddsShark.com NFL Database, pointing to another high-scoring matchup here.

Other key trends for this Philadelphia versus Indianapolis matchup that back a lot of points being scored include the OVER going 4-0 in the last four games when the Eagles are road underdogs and 6-1 in their past seven games against AFC South opponents. For those considering a moneyline play on the dog, Philly is also 5-1 SU in its last six road games.