Shorts, 26, has missed Jacksonville's first two games with a hamstring injury. He had 66 catches for 777 yards and three touchdowns last season for the Jaguars.
Hurns left Week 2's loss to Washington on crutches with an injured ankle. The undrafted rookie out of Miami is the team's leading receiver with 123 yards and two touchdowns on six catches.
Earlier this week, Jaguars coach Gus Bradley criticized the team's rookie receivers for making too many mental errors.
The Jaguars host the Indianapolis Colts in their home-opener on Sunday.
- Paul Palladino