Chargers running back Danny Woodhead will likely have season-ending surgery after suffering a "severe high ankle sprain" and fractured fibula, according to Alex Marvez of FOXSports.com.
Woodhead was carted off the field in San Diego's game Sunday against the Bills.
Replay shows that Danny Woodhead’s lower right leg/ankle bent awkwardly underneath him as he was tackled. Carted off. — Mike Rodak (@mikerodak) September 21, 2014
Mathews and Woodhead accounted for 118 of the Chargers' 153 rushing yards through the team's first two games.
Third string back Donald Brown was San Diego's top ball carrier Sunday. He had 31 carries for 62 yards.
- Will Green