The Denver Broncos opened as touchdown favorites over the Arizona Cardinals on the Week 5 NFL betting lines at sports books monitored by OddsShark.com, but it's the Cardinals who have opened the season with the better record both straight up and against the spread.
Arizona and Denver meet on Sunday afternoon coming off a Week 4 bye, with the Cardinals at 3-0 SU and 2-1 ATS and the Broncos at 2-1 SU but 0-3 ATS through the first four weeks. Still, it's worth considering ahead of this matchup that the Broncos are 13-3 ATS in their last 16 games after a bye week.
The Cincinnati Bengals are the only other undefeated team left in the league, and they return from their bye to a Sunday night matchup against the reeling New England Patriots. The Patriots opened as 2.5-point home favorites for that contest, but some books were offering the Bengals as slight road favorites by Tuesday night.
The San Diego Chargers own a perfect 4-0 mark against the spread heading into Week 5, and they opened as seven-point favorites at home this week against the New York Jets, who are struggling at 1-3 SU and 0-3-1 ATS on the season. Despite their weak start to the season, the Jets are 6-2 ATS in their eight most recent matchups with the Chargers.
The Jaguars are winless across the board at 0-4 SU and 0-4 ATS on the season as they look to break into the win column at home against a Pittsburgh Steelers team that opened as a seven-point favorite. The only other 0-4 team in the league is the Raiders, who are mercifully on a bye this week after losing in London and firing head coach Dennis Allen.
For those watching the point totals in Week 5, Arizona, Cincinnati and Buffalo have all failed to hit the over this season – with the Bills opening as a 6.5-point underdog on the road in Detroit for Sunday afternoon. At the other end of the spectrum, the Browns, Jaguars and Colts have hit the over in each one of their games so far this year. Indianapolis hosts Baltimore in Week 5 and opened as three-point favorites on the odds board.