Van Noy was placed on injured reserve with a designation to return at the beginning of the season and has not practiced since training camp. He underwent sports hernia surgery in August.
The Lions chose Van Noy in the second round of May's NFL draft. He was a third-team All-American in each of the last two years at BYU.
Van Noy can not be activated until after Detroit's Oct. 26 game against the Atlanta Falcons in London, but he is allowed to return to practice this week.
"There is a chance, from a medical standpoint, that this is going to be his week to start coming back to getting a little bit more involved," Caldwell said. "We'll see what that looks like come Wednesday."
TJ Jones, a rookie wide receiver for the Lions, is also eligible to return to practice this week. He had shoulder surgery in June.
Detroit defeated the Vikings 17-3 on Sunday, despite not having Calvin Johnson and Reggie Bush, who were both sitting with injuries.
The Lions (4-2) host the Saints (2-3) on Sunday.
- Molly Geary