Clowney has missed the team's last six games after injuring his knee in the first half of the Texans' season opener against the Washington Redskins on Sept. 7, tearing his meniscus and later undergoing surgery.
The rookie also missed time in the preseason as a precaution after a helmet-to-helmet collision and had surgery in June to repair a sports hernia.
Clowney had one tackle before his injury in the season opener. Whitney Mercilus has started in his place since the injury.
The Texans head into Sunday 26th in the NFL in total defense, allowing 387.3 yards per game.
- Ben Estes