Ayers was injured in Sunday's loss to the Jaguars. At his Monday news conference, Giants head coach Tom Coughlin declined to elaborate on Ayers' status, saying he would wait until he had more information.
Ayers signed a two-year contract with the Giants prior to this season. He spent his first five seasons with the Broncos after being selected 18th in the 2009 draft.
Ayers is tied with Jason Pierre-Paul for the team lead in sacks with five, one half sack behind his career-high.
The Giants currently have 13 players on injured reserve, more than any other team in the NFL. The list includes two of New York's top cornerbacks, Prince Amukamara and Walter Thurmond, as well as Pro-Bowl receiver Victor Cruz and starting middle linebacker Jon Beason.
- Dan Gartland