Spiller, who has been on IR for eight weeks due to a broken collarbone, enthusiastically confirmed the news on Twitter Monday afternoon.
CLEARED— Cj Spiller (@CJSPILLER) December 15, 2014
The Bills have won three of their last four, including a surprising 21-13 win over the Green Bay Packers on Sunday. At 8-6, the Bills are second in the AFC East, and if the playoffs started this weekend, they would miss out on a berth by a game. The Baltimore Ravens are currently the AFC's final seed at 9-5; the Kansas City Chiefs, San Diego Chargers and the Bills are all 8-6 and would settle into the seventh, eighth and ninth seeds, respectively.
Bills coach Doug Marrone said Monday he would like to monitor Spiller in practice before deciding whether to activate the fifth-year veteran for Sunday's game vs. the Oakland Raiders.
"He's cleared so I'm looking forward to seeing how he practices during the week," Marrone said to the Bills' website.
"He's a guy that's made plays in the past. Anytime you can bring back someone who is a potential playmaker, it obviously helps."
On the season, Spiller has 69 carries for 287 yards. He also has 14 receptions for 109 yards and one touchdown.
Last season, Spiller missed only one game, though he did spend most of the season dealing with a high-ankle sprain. For his career, Spiller has 659 carries for 3,308 yards and 12 touchdowns, plus 153 receptions for 1,179 yards and six touchdowns.
Fred Jackson -- who was also injured in Week 7 -- is Buffalo's leading rusher with 117 carries for 457 yards and two touchdowns. Anthony Dixon took many of Spiller's carries while he was out, rushing 95 times for 398 yards and one touchdown.
- Mike Fiammetta