The San Francisco 49ers (7-7) were eliminated from playoff contention with a 17-7 loss last week to the Seattle Seahawks and look to break a three-game long streak. San Diego (8-6) has lost two straight and look to remain in the AFC playoff hunt.
You can follow the game with live stats and play-by-play here.
How to watch
Details for Saturday’s game are below:
Kickoff: 8:25 p.m. ET
Live stream: The game can be live streamed here.
TV coverage: CBS
Week 15: Seahawks 17, 49ers 7
Marshawn Lynch rushed for 97 yards and one touchdown as Seattle officially ended San Francisco’s postseason hopes with a 17-7 victory. Colin Kaepernick threw for only 141 yards and was sacked six times. Seattle beat the 49ers for the fifth time in the last six meetings.
Week 14: Raiders 24, 49ers 13
Derek Carr threw for 254 yards and three touchdowns to damage the 49ers’ playoff hopes. Colin Kaepernick struggled throughout the game, throwing two interceptions and getting sacked five time. Oakland tight end Mychal Rivera caught seven passes for 109 yards and a touchdown, and Latavius Murray added 76 yards rushing for the Raiders, winners of two of their last three games.
Week 13: Seahawks 19, 49ers 3
The Seahawks limited the 49ers to just 164 yards of total offense in a convincing road win on Thanksgiving. Russell Wilson completed 15 of 22 passes for 236 yards and a touchdown, and Marshawn Lynch ran 20 times for 104 yards. Richard Sherman had two interceptions, and the Seahawks sacked Colin Kaepernick four times.
Week 12: 49ers 17, Redskins 13
The 49ers won their third straight game on Carlos Hyde's rushing touchdown with less than three minutes remaining. Colin Kaepernick completed 20 of 29 passes for 256 yards, one touchdown and one interception, and Anquan Boldin had 137 receiving yards on nine catches. Linebacker Aldon Smith had two sacks in his second game back from suspension.
Week 11: 49ers 16, Giants 10
San Francisco had five interceptions and the 49ers held on for a road win over the Giants. Chris Borland had two picks against Eli Manning, and Eric Reid, Chris Culliver and Michael Wilhoite each had one interception. Colin Kaepernick threw for 193 yards, Frank Gore ran for 95 yards and Michael Crabtree had 85 receiving yards and a touchdown.
Week 10: 49ers 27, Saints 24 OT
The 49ers benefited from a controversial pass interference call against Saints tight end Jimmy Graham to win in overtime. Colin Kaepernick completed 14 of 32 passes for 210 yards and a touchdown, and Frank Gore added 81 yards and a score on the ground. Phil Dawson's 35-yard field goal won the game in overtime.
Week 15: Broncos 22, Chargers 10
The Broncos clinched their fourth straight division title as Peyton Manning threw for 233 yards and one touchdown despite playing with an illness. The Broncos, who got five field goals from Connor Barth, also won their 12th straight division road game. Philip Rivers was picked off twice and San Diego only converted one of their five red zone trips into points.
Week 14: Patriots 23, Chargers 14
For the second straight game, the Patriots dug themselves a first-half deficit, but this time they rebounded to beat the Chargers. Tom Brady threw for 317 yards and two touchdowns as the Patriots scored the game's final 20 points. Julian Edelman caught eight balls for 141 yards, including a 69-yard touchdown catch in the fourth quarter to seal the victory. Linebacker Jamie Collins had two sacks for the Patriots.
Week 13: Chargers 34, Ravens 33
Philip Rivers threw a touchdown pass to Eddie Royal with 38 seconds remaining to push the Chargers to a road win over the Ravens. Rivers completed 34 of 45 passes for 383 yards, three touchdowns and an interception, and Keenan Allen led the team with 11 catches for 121 yards and two scores.
Week 12: Chargers 27, Rams 24
Marcus Gilchrist had an interception in the final minute to end a Rams' comeback attempt and seal the victory. Philip Rivers completed 29 of 35 passes for 291 yards, one touchdown and one interception, and Keenan Allen had 104 receiving yards and a touchdown. Ryan Matthews had a 32-yard rushing touchdown en route to 105 yards on the day.
Week 11: Chargers 13, Raiders 6
San Diego managed just 300 yards of total offense, but it was still enough to beat the then-winless Raiders. Philip Rivers threw a touchdown in the opening minute to Malcom Floyd, but the offense sputtered for the rest of the game. San Diego's defense made up for the offense's struggles by limiting the Raiders to 233 yards of offense.