Iupati, 28 in May, has played all five of his NFL seasons with the San Francisco 49ers. He has appeared in 16 games three times and played in 15 last season. Iupati is also a three-time Pro Bowler (2012-14) and was a first-team All-Pro selection in 2012.
The 49ers selected Iupati 17th overall in the 2010 draft. He made a $2.9 million base salary last season with a $4.6 million cap hit, the last of his rookie contract.
The Cardinals finished 11-5 last season, their best record since 1975. Arizona also made the postseason for the first time since 2009.
- Mike Fiammetta