Germany's Ilkay Gundogan, England's Alex Oxlade-Chamberlain and Italy's Marco Verratti have all been ruled out of Euro 2016 with respective injuries, their clubs announced.
Gundogan dislocated his kneecap in Borussia Dortmund training, the club announced, which will end his season and ruin his hopes of suiting up for the reigning World Cup champions in France this summer.
Oxlade-Chamberlain has suffered a setback in his return from a knee injury, according to Arsenal manager Arsene Wenger, and he will be out another 6-to-8 weeks.
"I had a conversation with Alex and with our medical team, and they told me he will back in July," Wenger said, according to the AP. "It is very sad. He was physically ready and looking sharp ... You want a guy of 22 years of age to go to the European Championship. It's very bad. He's an impact player as well so he could have had a great contribution to England's success."
Oxlade-Chamberlain first suffered the injury in February in a Champions League match against Barcelona. He was due back in action for Arsenal's U-21 side before re-injuring himself.
Verratti, meanwhile, needs surgery for a groin injury, his club, Paris Saint-Germain, announced Friday. Verratti will undergo the operation in Doha, Qatar, on May 16 and be out for the following eight weeks.