Florida State head coach Jimbo Fisher said O'Leary injured his ankle and was "skinned from head to toe."
O'Leary, the grandson of golfer Jack Nicklaus, caught 33 passes for 557 yards and seven touchdowns last season, helping the Seminoles win the BCS Championship.
Last May, O'Leary, who was an All-ACC second team selection in 2013, was involved in a motorcycle accident when a vehicle pulled in front of him, striking O'Leary, flipping him over the hood of the car. He did not miss any practice time after that accident.
"He needs to be frustrated, it's not important if I'm frustrated," Fisher said, via the Associated Press. "What's important is if he's frustrated and learned his lesson."