Portugal's Fabio Coentrao and Hugo Almeida both left Monday's 4-0 shellacking at the hands of the Germans early with injuries, according to ESPN.com.
The Portuguese medical staff believes both players will miss the team's final two group stage matches.
Coentrao, who was deployed in a midfield role for the match, made signals to be taken off on 62 minutes and was seen clutching his adductor, clearly in a lot of pain.
Afterwards Coentrao was not hopeful that he would be able to return in time to play any further part in Portugal's World Cup campaign.
He said: "I honestly think the World Cup is over for me. I'm sure it's a serious injury although I hope I'm wrong."
Coentrao and Almeida will undergo tests Tuesday and Wednesday, but the Portuguese team doctor says he believes they will be out "between 10 days and three weeks."
Portugal plays the U.S. on Sunday and will also be without the services of center back Pepe, who will serve a one game suspension after his red card Monday. PLANET FUTBOL: World Cup Daily Recap: USA's hero, Germany's domination, WC's 1st draw