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Arizona Cardinals vs. San Francisco 49ers NFL Week 5 Odds, Plays and Insights

The Arizona Cardinals (4-0) are favored by 5.5 points as they look to keep their four-game winning streak going in a matchup with the San Francisco 49ers (2-2) on Sunday, October 10, 2021 at State Farm Stadium. A total of 48.5 points has been set for this matchup.

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Odds for Cardinals vs. 49ers

Over/under insights

  • Arizona has combined with its opponents to score more than 48.5 points in all four games this season.
  • San Francisco's games have gone over 48.5 points in three of four chances this season.
  • Sunday's total is 13.3 points lower than the two team's combined 61.8 points per game average.
  • The 46.8 combined points per game that these two squads have allowed this season are 1.7 fewer than the 48.5 total in this contest.
  • The Cardinals and their opponents have scored an average of 52.4 points per game in 2020, 3.9 more than Sunday's total.
  • The 48.5-point over/under for this game is 0.9 points below the 49.4 points per game average total in 49ers games this season.
  • Against the spread, Arizona is 3-1-0 this year.
  • This season, the Cardinals won ATS in their only game as a favorite of 5.5 points or more.
  • Arizona's games this year have gone over the total in two out of four opportunities (50%).
  • This year, the Cardinals put up 9.5 more points per game (35) than the 49ers surrender (25.5).
  • Arizona is 3-1 against the spread and 4-0 overall this season when the team scores more than 25.5 points.
  • The Cardinals collect 103.7 more yards per game (440.5) than the 49ers allow per matchup (336.8).
  • Arizona is 3-1 against the spread and 4-0 overall when the team picks up more than 336.8 yards.
  • This year, the Cardinals have turned the ball over four times, three more than the 49ers' takeaways (1).
  • Click over to SISportsbook and find the latest spread, moneyline and total for Arizona's matchup with the 49ers.
  • San Francisco has covered the spread once this season.
  • San Francisco's games this season have hit the over two times in four opportunities (50%).
  • This season the 49ers rack up 5.5 more points per game (26.8) than the Cardinals allow (21.3).
  • When San Francisco scores more than 21.3 points, it is 0-2 against the spread and 1-1 overall.
  • The 49ers rack up only 18.5 more yards per game (375.8) than the Cardinals give up per outing (357.3).
  • In games that San Francisco totals over 357.3 yards, the team is 0-2 against the spread and 1-1 overall.
  • The 49ers have turned the ball over six times, three fewer times than the Cardinals have forced turnovers (9).

Home and road insights

  • The average point total in Cardinals home games this season is 50.5 points, 2.0 more than this contest's over/under (48.5).
  • The 49ers are winless ATS (0-1) away from home as 5.5-point underdogs or more.
  • 49ers away games this season average 47.5 total points, 1.0 fewer than this contest's over/under (48.5).

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