Margarito suffered a gruesome decision loss to Pacquiao in a showdown for the vacant WBC super welterweight title at Cowboys Stadium.
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Perhaps distracted by the career-threatening illegal hand-wrap revelation from before the fight, Margarito was comprehensively outclassed by Mosley, who won the WBA welterweight title with an 11th-round knockout.
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Margarito vacated the IBF welterweight title by opting against a rematch with mandatory challenger Joshua Clottey, clearing the way for a showdown with Cotto, the undefeated WBA 147-pound beltholder. In one of the fights of the year , Margarito stormed from behind to score a devastating 11th-round TKO.
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Kermit Cintron II
Margarito became a two-time world titlist with a thrilling sixth-round knockout of Cintron, who'd gained the IBF welterweight belt since their first meeting.
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Margarito returned to the win column with a first-round knockout of Johnson on the undercard of the Miguel Cotto-Shane Mosley main event in New York.
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Margarito ceded the WBO title after losing a unanimous decision to Williams, the long-limbed challenger who connected with twice as many punches but didn't necessarily land the more damaging shots.
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Ring rust from a 10-month layoff seemed to affect Margarito early in his seventh WBO title defense, but the Mexican heated up down the stretch and coasted to a unanimous decision over the stubborn Clottey.
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Kermit Cintron I
Cintron was 24-0 entering a highly anticipated showdown with Margarito for the 147-pound title, but suffered four knockdowns before his corner threw in the towel at 2:21 of the fifth round.
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Margarito captured his first world title just two days before his 24th birthday with a 10th-round TKO of Diaz for the WBO welterweight belt. He'd defend the title seven times over the next five years, including five knockouts.
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