These days, it's simply a chance for another batch of talented transfers to thrive under coach Fred Hoiberg.
They've both moved on, but 14th-ranked Iowa State is confident it can replace their production - and perhaps surpass it - entering Friday night's opener against Oakland.
Former UNLV standout Bryce Dejean-Jones averaged 13.6 points and should be among the Big 12's top guards. Marquette transfer Jameel McKay is expected to be Hoiberg's first true shot blocker and Abdel Nader, a 6-foot-7 wing player who sat out after transferring from Northern Illinois, has the size and versatility Hoiberg craves along the perimeter.
That trio will join a core group of returnees who've proven they know how to win.
Junior forward Georges Niang is a serious conference player of the year candidate. Point guard Monte Morris set the NCAA record with an assist-to-turnover ratio of 4.79 as a freshman last season, and Hoiberg believes senior forward Dustin Hogue's 34-point outburst in the season finale against Connecticut was a sign of things to come.
The key for Iowa State (28-8) will be making all those promising pieces fit together, something they've always seemed to accomplish under Hoiberg.
"The thing about (last year's) team that was so much fun to coach is how those guys came together and had one common goal," Hoiberg said. "That's what I'm looking for with this group."
The 6-foot-8 Niang may have been Iowa State's most important player because of his ability to defend in the paint and stretch the floor offensively. Niang's season-ending foot injury in the second round of the NCAA tournament was too much to overcome for the Cyclones, who fell to eventual champion UConn at Madison Square Garden.
Niang has since lost about 25 pounds, which he hopes will allow him to stay on the floor longer. He averaged 16.7 points and 4.5 rebounds last season.
Dejean-Jones has drawn inevitable comparisons to Kane, also a fifth-year transfer. But Dejean-Jones is more of a traditional shooting guard than Kane, though he can play the point if Morris needs a breather.
Dejean-Jones was named the Big 12's preseason newcomer of the year.
"DeAndre is probably a guy that would dominate the ball more than Bryce. Bryce is probably a guy that has better range," Hoiberg said.
Morris' nickname is "Man-Man," a moniker that's more fitting than ever. Morris will run Iowa State's high-flying attack after a freshman season so promising that he forced Hoiberg to start him alongside Kane by late January.
The Cyclones might be exposed a bit if Morris goes down, though, since the only other true point guard on the roster is freshman Clayton Custer.
McKay can't play until Dec. 20 after leaving Marquette in the middle of his first semester there, but he's expected to be a major piece for the Cyclones as soon as he's eligible. A two-time All-American at Indian Hills Community College in Iowa, McKay is an athletic center at 6-foot-9 and 215 pounds who can run the floor and protect the rim.
Greek freshman Georgios Tsalmpouris, a 7-foot-1 project, will help fill McKay's absence in non-conference play.
Iowa State has plenty of options along the perimeter. Nader gives the Cyclones the option of going big by playing small forward or going small by playing power forward. Guard Naz Long shot 40 percent from 3-point range in 2014-15, and the Cyclones remain high on sophomore Matt Thomas despite an up-and-down first season in Ames.
"We will have tremendous depth on this team, and I'm excited about that depth," Hoiberg said.
It seems likely Hoiberg will go deep into his bench Friday against Oakland, which has been picked to finish seventh in the Horizon League after going 13-20 last season.
The Golden Grizzlies are led by first-team all-league selection Corey Petros and reigning Horizon freshman of the year Kahlil Felder. Petros is the team's top returning scorer (13.3 points per game) and led the Horizon with 8.2 rebounds per game last season. Felder broke the league freshman record with 212 assists.
Coach Greg Kampe enters his 31st season as Oakland coach - only Syracuse's Jim Boeheim (39) and Duke's Mike Krzyzewski (35) currently have longer tenures. Kampe ranks 21st among active Division I coaches with 519 wins.
The Golden Grizzlies, who have never faced Iowa State, are 2-35 against ranked opponents after losing four such matchups last season by an average of 18.2 points.