Lorenzo Cugini hit a jumper with 6:02 left, tying the game at 54 and sparking an 18-3 run by High Point (2-0) over the next 4:04 that put the game out of reach.
UAPB made just 1 of 7 field goals during that time.
Marcel Mosley led UAPB (0-2) with 26 points on 9-of-16 shooting, but the rest of the team shot 37 percent. Jovaughn Love scored 12.
High Point made 25 of 47 field goals and 17 of 21 free throws.