Tollefsen's dunk with 8:44 left in the second half gave San Francisco a 70-31 lead and the Dons played even with SC State (0-2) the rest of the way.
USF shot 12 of 25 (48 percent) from 3-point range and 36 of 62 (58.1 percent) overall. Tollefsen was 6 of 11 from the field and Pinkins 7 of 9. Derksen shot 6 of 8 from the field with seven boards, four assists and three steals.
The Dons opened on a 24-6 run and led 45-18 at halftime.
Karon Wright scored 13 points to lead the Bulldogs who shot 18 of 62 (29 percent) from the field.