Miller did not attempt another 3 the rest of the night and the Spartans (2-0) didn't need him to, pulling away steadily.
SC-Upstate took a 29-20 lead at intermission and outscored the Aggies 34-26 in the second half.
Ty Greene led SC-Upstate with 20 points, hitting 7 of 13 from the field and 4 of 7 from long range. Miller finished with 11 points.
The Spartans shot 24 of 63 from the field as a team and were 9 of 24 from behind the arc, but held North Carolina A&T to just 32 percent on 16 of 50 shooting. The Aggies were just 3 of 20 from long range.
Bruce Beckford had a dozen points for the Aggies (1-1).