D'Andre Wright added 14 points, on 6-of-10 shooting, for Tulsa (2-1).
Tulsa has held 32 straight opponents to less than 50 percent shooting from the floor.
Louisiana Lafayette held Tulsa's James Woodard to four points, ending his 28-game streak of scoring in double figures.
Shawn Long led Louisiana Lafayette (1-2) with 15 points and grabbed four rebounds to bring his career total boards to 700, but the Ragin Cajuns were outrebounded 37-31. Brian Williams scored nine points.
Tulsa led 32-21 at halftime and forced the Ragin Cajuns to commit 25 turnovers for the game.