Abilene Christian (1-2) led 13-12 midway of the second half. The Dukes quickly took control to lead 46-38 at the half. The Wildcats had trimmed the lead to 54-48 with 14:58 remaining, but the Dukes went on a 27-12 run to pull ahead 81-60 with 7:42 left in the game.
Duquesne won the rebound battle, pulling down 40 to ACU's 30.
ACU's Parker Wentz, who made 4 of 5 3-point attempts, totaled 31 points. He made 8 of 13 field goal attempts and hit 11 of 12 free throw shots.
Harrison Hawkins added 17 points for the Wildcats.