Okoloji had two layups and Lee hit a 3-pointer to spark an 11-0 run that put Eastern Michigan ahead by double digits for good. The Eagles led by 14 at half and pulled away with a 14-0 run to open the second half.
Eastern Michigan outscored Longwood 34-20 in the paint and had 25 points off turnovers.
The Lancers (2-3) held an early lead, but couldn't keep pace, stumbling to shoot 18 of 55 (32.7 percent) and committing 24 turnovers. Lotanna Nwogbo scored 14 points and Ryan Badowski contributed 12 for Longwood.