The Crimson (3-1) opened the game on a 13-3 run sparked by two free throws and a layup from Saunders along with Chambers' 3-pointer, leading them to a 43-34 halftime lead. Miller drilled a 3-pointer to cap a 17-6 surge to open the second half, pushing Harvard's lead to 20 with 12:23 remaining.
The Cougars (2-1) were limited to 21-of-63 shooting and couldn't keep pace despite hitting 10 3-pointers. Harvard out-rebounded Houston 43-32 and took advantage of 23 fouls, going 22 of 26 from the free throw line.
Eric Weary Jr. led Houston with 19 points.