After losing its season opener, Hartford (5-1) has won five straight and is off to the best start in the program's 31-year Division I history.
Emerson stayed close in the first half, trailing only 32-26 at the break.
Hartford opened the second with a 23-10 run and extended to 70-36 with 15 straight points.
Michael Thorpe was 4 of 7 from 3-point range to lead Emerson with 12 points. The Lions couldn't overcome 21 turnovers and 30.2 percent shooting from the field.