Bernardi hit six 3-pointers and Tanksley five from beyond the arc for the Pride (4-2), who snapped a 17-game non-conference road losing skid.
Hofstra led 37-25 at the break. Jackson State had a 13-6 run to pull within six, 44-38, with 12:45 to play. Tanksley hit a 3 and scored on a putback to make it 49-38 with less the 12 minutes left before using a 31-6 run to pull away.
Juan'ya Green finished with 14 points and had six assists and three steals for Hofstra.