Lee made had three 3-pointers and 19 points at the break to give the Dragons (2-4) almost all the points they would need at 35-21. Drexel used an 8-1 run to go up 55-32 in the second and finished with their best defensive effort since a 60-27 victory over Towson on Jan. 4, 2012.
Rodney Williams added 12 points and Drexel shot 24 of 50 from the field while holding Southern Miss (3-2) to 15 of 47.
Norville Carey had 14 of his 16 points in the first half for the Golden Eagles. He made six of his first seven shots while his teammates missed their first 11; no one picked up the slack once Carey cooled off.