Nance made 6 of 7 field goal attempts to score 17, Adams had 11 and Hankerson contributed 10 for Wyoming (7-0).
The Cowboys, who have shot 50 percent or better in every game this season, made 22 of 37 from the floor (59.5 percent) against Denver. The Pioneers became the fifth opponent that Wyoming has held under 50 points this season.
Wyoming also won the battle underneath, scoring 32 points in the paint compared to 18 for the Pioneers.
The Cowboys held a slim 27-20 lead at the half but opened the second period with a 9-0 run that led to a 49-29 lead at the midway point as they coasted to the win.
Cam Griffin led Denver (3-3) with 13 points.